Abstract: In order to find the measure of controlling the fusarium wilt disease of banana，through pot experiments and laboratory experiments，we investigated the applied effects of EDTA-Cu and EDTA-Zn on the physiological characteristics of Fusarium oxysporum f. sp. cubense，and the combined application of Zn²⁺ and the fungal antagonist of the No. 21 bacteria（SQR21^#，Paenibacillus polymyxa）on the suppression on the disease. The results were as follows：（1）Time of 96 hours after treatment the banana seedlings with crude toxin of Fusarium oxysporum f. sp. cubense，the seedlings of the control treatment wilted severely. However，the treatments of application of EDTA-Cu and EDTA-Zn significantly reduced the disease stress on banana.（2）Application of EDTA-Cu and EDTA-Znsignificantly increased the total biomass and the microconidium number of Fusarium oxysporum f. sp. cubense，but significantly reduced the production of fusaric acid of Fusarium oxysporum f. sp. cubense. Compared with the control treatment，the fusaric acid production with treatments of EDTA-Cu and EDTA-Zn were reduced by 73% and 96%，respectively.（3）In pot experiments，only Zn²⁺ addition significantly reduced the banana fusarium wilt disease index. Furthermore，combined application of Zn²⁺ and the No. 21 bacteria had a good effect of cotrolling the disease，and after 75 days of inoculation of banana seedlings，the banana fusarium wilt disease indices were all reduced by 62% compared with the only fungi-inoculated treatment.（4）Only addition of the No. 21 bacteria reduced the spore number by 18% compared to the only fungi-inoculated treatment. However，when combined application of Zn and No. 21 bacteria，the number of the spores was increased significantly by 30%. It was concluded that Zn application might effectively reduce the occurrence of fusarium wilt disease of banana though reducing the fusaric acid production of the pathogen and enhancing the No. 21 bacteria biocontrol activity.

Key words: banana, copper, zinc, Paenibacillus polymyxa, fusarium wilt disease, fusaric acid