Progress in the Study of Glycosidealkaloids and Their Biological Activities in Solanaceae Vegetable

doi:10.16420/j.issn.0513-353x.2023-0492

Acta Horticulturae Sinica ›› 2024, Vol. 51 ›› Issue (9): 2207-2218.doi: 10.16420/j.issn.0513-353x.2023-0492

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Progress in the Study of Glycosidealkaloids and Their Biological Activities in Solanaceae Vegetable

LIU Yu¹^,², ZHANG Min¹, TAN Jie¹, HUANG Shuping¹, ZHANG Hongyuan¹, WANG Benqi¹, WANG Junliang¹, CHEN Huilan², CHEN Xia¹^,^*()

¹ Wuhan Vegetable Research Institute，Wuhan Academy of Agricultural Science and Technology，Wuhan 430065，China
² School of Horticulture and Forestry，Huazhong Agricultural University，Wuhan 430070，China

Received:2024-07-13 Revised:2024-09-01 Online:2024-09-25 Published:2024-09-19
Contact: CHEN Xia

Abstract

Abstract:

Glycoalkaloid is a secondary metabolite widely present in Solanaceae plants. It has a certain impact on the quality and food safety of Solanaceae vegetables. In order to provide reference for researchers in related fields，this article analyzes and summarizes the researches about the glycoalkaloid in Solanaceae vegetables，including factors affecting their content，biological activity，and mechanism of action，etc.

Key words: Solanaceae vegetable, glycoalkaloid, distribution, biological activity, mechanism

LIU Yu, ZHANG Min, TAN Jie, HUANG Shuping, ZHANG Hongyuan, WANG Benqi, WANG Junliang, CHEN Huilan, CHEN Xia. Progress in the Study of Glycosidealkaloids and Their Biological Activities in Solanaceae Vegetable[J]. Acta Horticulturae Sinica, 2024, 51(9): 2207-2218.

References 88

[1]	Abreu P, Relva A, Matthew S, Gomes Z, Morais Z. 2007. High-performance liquid chromatographic determination of glycoalkaloids in potatoes from conventional,integrated,and organic crop systems. Food Control, 18 (1):40-44.
[2]	Al Sinani S S S, Eltayeb E A. 2017. The steroidal glycoalkaloids solamargine and solasonine in Solanum plants. South African Journal of Botany,112:253-269.
[3]	Bagheri M, Shahnejat Bushehri A A, Hassandokht M R, Naghavi M R. 2017. Evaluation of solasonine content and expression patterns of SGT1 gene in different tissues of two iranian eggplant(Solanum melongena L.)genotypes. Food Technology and Biotechnology, 55 (2):236-242.
[4]	Bajaj K L, Kaur G, Chadha M L. 1979. Glycoalkaloid content and other chemical constituents of the fruits of some eggplant(Solanum melongena L.). Journal of Plant Foods, 3 (3):163-168.
[5]	Blankemeyer J T, McWilliams M L, Rayburn J R, Weissenberg M, Friedman M. 1998. Developmental toxicology of solamargine and solasonine glycoalkaloids in frogembryos. Food Chemical Toxicologe, 36 (5):383-389.
[6]	Blankemeyer J T, White J B, Stringer B K, Friedman M. 1997. Effect of α-tomatine and tomatidine on membrane potential of frog embryos and active transport of ions in frog skin. Food and Chemical Toxicology, 35 (7):639-646. pmid: 9301646
[7]	Campbell B C, Duffey S S. 1981. Alleviation of α-tomatine-induced toxicity to the parasitoid,Hyposoter exiguae,by phytosterols in the diet of the host, Heliothis zea. Journal of Chemical Ecology,7:927-946.
[8]	Cárdenas P D, Sonawane P D, Heinig U, Bocobza S E, Burdman S, Aharoni A. 2015. The bitter side of the nightshades:genomics drives discovery in Solanaceae steroidal alkaloid metabolism. Phytochemistry,113:24-32.
[9]	Cárdenas P D, Sonawane P D, Pollier J, Vanden Bossche R, Dewangan V, Weithorn E, Tal L, Meir S, Rogachev I, Malitsky S, Giri A P, Goossens A, Burdman S, Aharoni A. 2016. GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. Nature Communications,7:10654.
[10]	Chen Jing, Wang Zhimin, Tang Qinglin, Niu Yi, Tian Shibing, Wang Yongqing, Song Ming. 2011. Progress of mechanism of health protection and medication in eggplants. Journal of Changjiang Vegetables,(8):1-3. (in Chinese)
	陈静, 王志敏, 汤青林, 牛义, 田时炳, 王永清, 宋明. 2011. 茄子的药用价值及机理研究进展. 长江蔬菜,(8):1-3.
[11]	Chen Yongliang, Chen Baodong, Liu Lei, Hu Yajun, Xu Tianle, Zhang Xin. 2014. The role of arbuscular mycorrhizal fungi in soil nitrogen cycling. Acta Ecologica Sinica, 34 (17):4807-4815. (in Chinese)
	陈永亮, 陈保冬, 刘蕾, 胡亚军, 徐天乐, 张莘. 2014. 丛枝菌根真菌在土壤氮素循环中的作用. 生态学报, 34 (17):4807-4815.
[12]	Chen Z, Miller A R. 2000. Steroidal alkaloids in Solanaceous vegetable crops. Horticultural Reviews,25:171-196.
[13]	Clementino L D C, Velásquez A M A, Passalacqua T G, de Almeida L, Graminha M A S, Martins G Z, Salgueiro L, Cavaleiro C, Sousa M D C, Moreira R R D. 2018. In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum. Revista Brasileira de Farmacognosia, 28 (6):673-677.
[14]	Dale M, Griffiths D W, Bain H, Todd D. 1993. Glycoalkaloid increase in Solarium tuberosum on exposure to light. Annals of Applied Biology, 123 (2):411-418.
[15]	del Giudice R, Raiola A, Tenore G C, Frusciante L, Barone A, Monti D M, Rigano M M. 2015. Antioxidant bioactive compounds in tomato fruits at different ripening stages and their effects on normal and cancer cells. Journal of Functional Foods,18:83-94.
[16]	Dong Y, Hao L, Shi Z, Fang K, Yu H, Zang G, Fan T, Han C. 2022. Solasonine induces apoptosis and inhibits proliferation of bladder cancer cells by suppressing NRP1 expression. Journal of Oncology,2022:7261486.
[17]	Echeverría C, Martin A, Simon F, Salas C O, Nazal M, Varela D, Pérez-Castro R A, Santibanez J F, Valdés-Valdés R O, Forero-Doria O. 2022. in vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma. Frontiers in Pharmacology,13:1003264.
[18]	El-Hawary S S, Mohammed R, AbouZid S F, Bakeer W, Ebel R, Sayed A M, Rateb M E. 2016. Solamargine production by a fungal endophyte of Solanum nigrum. Journal of Applied Microbiology, 120 (4):900-911. doi: 10.1111/jam.13077 pmid: 26811095
[19]	Fewell A M, Roddick J G. 1993. Interactive antifungal activity of the glycoalkaloids α-solanine and α-chaconine. Phytochemistry, 33 (2):323-328.
[20]	Filderman R B, Kovacs B A. 1969. Anti-inflammatory activity of the steroid alkaloid glycoside,tomatine. British Journal of Pharmacology, 37 (3):748. pmid: 5348476
[21]	Friedman M, Huang V, Quiambao Q, Noritake S, Liu J, Kwon O, Chintalapati S, Young J, Levin C E, Tam C. 2018. Potato peels and their bioactive glycoalkaloids and phenolic compounds inhibit the growth of pathogenic trichomonads. Journal of Agricultural and Food Chemistry, 66 (30):7942-7947. doi: 10.1021/acs.jafc.8b01726 pmid: 30039703
[22]	Friedman M, Levin C E, Lee S, Kim H, Lee I, Byun J, Kozukue N. 2009. Tomatine-containing green tomato extracts inhibit growth of human breast,colon,liver,and stomach cancer cells. Journal of Agricultural and Food Chemistry, 57 (13):5727-5733. doi: 10.1021/jf900364j pmid: 19514731
[23]	Ge J, Wang P, Ma H, Zhang J. 2022. Solamargine inhibits prostate cancer cell growth and enhances the therapeutic efficacy of docetaxel via akt signaling. Journal of Oncology,2022:1-11.
[24]	Gee J M, Wortley G M, Johnson I T, Price K R, Rutten A A J J, Houben G F, Penninks A H. 1996. Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro. Toxicology in Vitro, 10 (2):117-128. pmid: 20650190
[25]	Ghazi M, Matthees D P. 1990. Quantitative inhibitory effects of steroidal alkaloids:Relative involvement of aglycones and sugar moieties on lettuce seed radicle elongation. Botanical Gazette, 151 (1):38-40.
[26]	Güntner C, Vázquez Á, González G, Usubillaga A, Ferreira F, Moyna P. 2000. Effect of solanum glycoalkaloids on potato aphid,Macrosiphum euphorbiae:Part II. Journal of Chemical Ecology, 26 (5):1113-1121.
[27]	Hall C A, Hobby T, Cipollini M. 2006. Efficacy and mechanisms of α-solasonine-and α-solamargine-induced cytolysis on two strains of trypanosoma cruzi. Journal of Chemical Ecology, 32 (11):2405-2416.
[28]	Han Y, Shi J, Xu Z, Zhang Y, Cao X, Yu J, Li J, Xu S. 2022. Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids. Frontiers in Pharmacology,13:802168.
[29]	Han Lijun, Fan Xiao, Fang Guoming. 2000. Effect of seaweed extract on the germination of vegetable seeds. Marine Sciences,(11):8-10. (in Chinese)
	韩丽君, 范晓, 房国明. 2000. 海藻提取物对蔬菜种子萌芽的影响. 海洋科学,(11):8-10.
[30]	Hu Bing, An Hongmei, Yan Xia, Zheng Jialu, Huang Xiaowei, Li Miao. 2018. Effects of solamargine on proliferation and apoptosis in colorectal carcinoma RKO cells. Lishizhen Medicine and Materia Medica Research, 29 (8):1839-1841. (in Chinese)
	胡兵, 安红梅, 闫霞, 郑佳露, 黄晓伟, 李淼. 2018. 澳洲茄边碱对大肠癌RKO细胞增殖和凋亡作用. 时珍国医国药, 29 (8):1839-1841.
[31]	Hu Bing, An Hongmei, Yan Xia, Zheng Jialu, Huang Xiaowei, Li Miao. 2019. Effects of solamargine on proliferation and apoptosis of colorectal carcinoma HCT 116 cells. Acta Chinese Medicine and Pharmacology, 47 (1):61-63. (in Chinese)
	胡兵, 安红梅, 闫霞, 郑佳露, 黄晓伟, 李淼. 2019. 龙葵单体澳洲茄边碱对大肠癌HCT116细胞增殖和凋亡作用. 中医药学报, 47 (1):61-63.
[32]	Itkin M, Heinig U, Tzfadia O, Bhide A J, Shinde B, Cardenas P D, Bocobza S E, Unger T, Malitsky S, Finkers R, Tikunov Y, Bovy A, Chikate Y, Singh P, Rogachev I, Beekwilder J, Giri A P, Aharoni A. 2013. Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes. Science, 341 (6142):175-179. doi: 10.1126/science.1240230 pmid: 23788733
[33]	Jared J J, Murungi L K, Wesonga J, Torto B. 2016. Steroidal glycoalkaloids:chemical defence of edible African nightshades against the tomato red spider mite, Tetranychus evansi (Acari:Tetranychidae). Pest Management Science, 72 (4):828-836.
[34]	Ji Yanlin, Wang Wangtian, Wang Di, Zhang Jinwen, Wang Wei, Li Ying, Zhang Feifei. 2010. Inducing effects of different light qualities on steroidal glycoalkaloids contents in potato tuber. Jiangsu Journal of Agricultural Sciences, 26 (1):40-45. (in Chinese)
	季彦林, 王旺田, 王蒂, 张金文, 王威, 李瑛, 张菲菲. 2010. 不同光质对马铃薯块茎糖苷生物碱积累的诱导效应. 江苏农业学报, 26 (1):40-45.
[35]	Keukens E A J, de Vrije T, Jansen L A M, de Boer H, Janssen M, de Kroon A I P M, Jongen W M F, de Kruijff B. 1996. Glycoalkaloids selectively permeabilize cholesterol containing biomembranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1279 (2):243-250.
[36]	Kozukue N, Han J, Lee K, Friedman M. 2004. Dehydrotomatine and α-tomatine content in tomato fruits and vegetative plant tissues. Journal of Agricultural and Food Chemistry, 52 (7):2079-2083.
[37]	Lelario F, de Maria S, Rivelli A R, Russo D, Milella L, Bufo S A, Scrano L. 2019. A complete survey of glycoalkaloids using lc-fticr-ms and irmpd in a commercial variety and a local landrace of eggplant(Solanum melongena L.) and their anticholinesterase and antioxidant activities. Toxins, 11 (4):230.
[38]	Leonardi C, Ambrosino P, Esposito F, Fogliano V. 2000. Antioxidative activity and carotenoid and tomatine contents in different typologies of fresh consumption tomatoes. Journal of Agricultural and Food Chemistry, 48 (10):4723-4727. doi: 10.1021/jf000225t pmid: 11052724
[39]	Lezama-Dávila C M, McChesney J D, Bastos J K, Miranda M A, Tiossi R F, Da Costa J D C, Bentley M V, Gaitan-Puch S E, Isaac-Márquez A P. 2016. A new antileishmanial preparation of combined solamargine and solasonine heals cutaneous leishmaniasis through different immunochemical pathways. Antimicrobial Agents and Chemotherapy, 60 (10):2732-2738.
[40]	Liang X, Hu C, Han M, Liu C, Sun X, Yu K, Gu H, Zhang J. 2022. Solasonine inhibits pancreatic cancer progression with involvement of ferroptosis induction. Frontiers in Oncology,12:834729.
[41]	Li Longmei, Huang Jinpeng, He Wenfeng, Li Qiuping, Wu Wanyin, Long Shunqin. 2020. Molecular mechanism of apoptosis induced by solasonine extracted from Solanum nigrum in A 549 cells. Traditional Chinese Drug Research and Clinical Pharmacology, 31 (12):1422-1427. (in Chinese)
	李龙妹, 黄锦鹏, 河文峰, 李秋萍, 吴万垠, 龙顺钦. 2020. 龙葵提取物澳洲茄碱诱导A549细胞凋亡的机制研究. 中药新药与临床药理, 31 (12):1422-1427.
[42]	Liu J, Kanetake S, Wu Y, Tam C, Cheng L W, Land K M, Friedman M. 2016. Antiprotozoal effects of the tomato tetrasaccharide glycoalkaloid tomatine and the aglycone tomatidine on mucosal trichomonads. Journal of Agricultural and Food Chemistry, 64 (46):8806-8810. pmid: 27934291
[43]	Li Yulu, Kuang Peilin, Tang Lijun, Yu Junlei, Luo Bin. 2021. Determination of α-solanine and α-chaconine in solanaceous vegetables and their products by high performance liquid chromatography-tandem mass spectrometry. Journal of Food Safety and Quality, 12 (3):1066-1075. (in Chinese)
	李雨露, 匡佩琳, 唐丽君, 喻俊磊, 罗斌. 2021. 高效液相色谱—串联质谱法测定茄科蔬菜及其制品中α-茄碱和α-卡茄碱的含量. 食品安全质量检测学报, 12 (3):1066-1075.
[44]	Li Yuzhu, Guo Huachun, Wang Qiong. 2020. Accumulation of steroidal glycoalkaloids in organs of different potato varieties. Science and Technology of Food Industry, 41 (22):1-7,13. (in Chinese)
	李玉珠, 郭华春, 王琼. 2020. 马铃薯不同品种各器官糖苷生物碱累积规律研究. 食品工业科技, 41 (22):1-7,13.
[45]	Li Zhiwen. 2009. Distribution of eggplant glycoalkaloid and its chemical ecological function[Ph. D. Dissertation]. Shenyang: Shenyang Agricultural University. (in Chinese)
	李志文. 2009. 茄子体内糖苷生物碱的含量分布特征及其化学生态学功能研究[博士论文]. 沈阳: 沈阳农业大学.
[46]	Mauro R P, Agnello M, Rizzo V, Graziani G, Fogliano V, Leonardi C, Giuffrida F. 2020. Recovery of eggplant field waste as a source of phytochemicals. Scientia Horticulturae,261:109023.
[47]	Mennella G, Lo Scalzo R, Fibiani M, D Alessandro A, Francese G, Toppino L, Acciarri N, de Almeida A E, Rotino G L. 2012. Chemical and bioactive quality traits during fruit ripening in eggplant(S. melongena L.) and allied species. Journal of Agricultural and Food Chemistry, 60 (47):11821-11831.
[48]	Milner S E, Brunton N P, Jones P W, O Brien N M, Collins S G, Maguire A R. 2011. Bioactivities of glycoalkaloids and their aglycones from Solanum species. Journal of Agricultural and Food Chemistry, 59 (8):3454-3484.
[49]	Muhammad A A, Shahira M E, Fatma S E, Gehan M K, Mostafa A A K. 2015. Impact of certain Solanum speciess natural products as potent cytotoxic and anti-Inflammatory agents. Journal of Medicinal Plants Research, 9 (29):779-786.
[50]	Najm A A, Hadi M R H S, Fazeli F, Darzi M T, Rahi A. 2012. Effect of integrated management of nitrogen fertilizer and cattle manure on the leaf chlorophyll,yield,and tuber glycoalkaloids of agria potato. Communications in Soil Science and Plant Analysis, 43 (6):912-923.
[51]	Ohyama K, Okawa A, Moriuchi Y, Fujimoto Y. 2013. Biosynthesis of steroidal alkaloids in Solanaceae plants:involvement of an aldehyde intermediate during C-26 amination. Phytochemistry,89:26-31.
[52]	Ono H, Kozuka D, Chiba Y, Horigane A, Isshiki K. 1997. Structure and cytotoxicity of dehydrotomatine,a minor component of tomato glycoalkaloids. Journal of Agricultural and Food Chemistry, 45 (10):3743-3746.
[53]	Patel B, Schutte R, Sporns P, Doyle J, Jewel L, Fedorak R N. 2002. Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease. Inflammatory Bowel Disease, 8 (5):340-346.
[54]	Peng Huan, Liu Hui, Jiang Ru, Ge Jianjun, Zhao Shouqi, Feng Xiaodong, Huang Wenkun, Peng Deliang. 2020. Potential invasion of the potato cyst nematode Gloodera Rostochiensis and G. Pallida into China. Plant Protection, 46 (6):1-9. (in Chinese)
	彭焕, 刘慧, 江如, 葛建军, 赵守歧, 冯晓东, 黄文坤, 彭德良. 2020. 警惕检疫性有害生物马铃薯孢囊线虫(Globodera rostochiensis和G.pallida)入侵我国. 植物保护, 46 (6):1-9.
[55]	Piana M, Camponogara C, Boligon A A, Oliveira S M. 2017. Solanum paranense extracts and solanine present anti-inflammatory activity in an acute skin inflammation model in mice. Evidence-Based Complementary and Alternative Medicine,2017:4295680.
[56]	Roddick J G. 1989. The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones. Phytochemistry, 28 (10):2631-2634.
[57]	Roddick J G, Rijnenberg A L, Weissenberg M. 1990. Membrane-disrupting properties of the steroidal glycoalkaloids solasonine and solamargine. Phytochemistry, 29 (5):1513-1518.
[58]	Roddick J G, Rijnenberg A L, Weissenberg M. 1992. Alterations to the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine. Phytochemistry, 31 (6):1951-1954.
[59]	Sabatino L, Consentino B B, Ntatsi G, La Bella S, Baldassano S, Rouphael Y. 2022. Stand-alone or combinatorial effects of grafting and microbial and non-microbial derived compounds on vigour,yield and nutritive and functional quality of greenhouse Eggplant. Plants, 11 (9):1175.
[60]	Sabatino L, Iapichino G, Consentino B B, D Anna F, Rouphael Y. 2020. Rootstock and arbuscular mycorrhiza combinatorial effects on eggplant crop performance and fruit quality under greenhouse conditions. Agronomy, 10 (5):693.
[61]	Salehi B, Sharifi-Rad R, Sharopov F, Namiesnik J, Roointan A, Kamle M, Kumar P, Martins N, Sharifi-Rad J. 2019. Beneficial effects and potential risks of tomato consumption for human health:an overview. Nutrition,62:201-208.
[62]	Sandrock R W, Vanetten H D. 1998. Fungal sensitivity to and enzymatic degradation of the phytoanticipin alpha-tomatine. Phytopathology, 88 (2):137-143. doi: 10.1094/PHYTO.1998.88.2.137 pmid: 18944982
[63]	Schrenk D, Bignami M, Bodin L, Chipman J K, Del M J, Hogstrand C, Hoogenboom L R, Leblanc J C, Nebbia C S, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Wallace H, Brimer L, Cottrill B, Dusemund B, Mulder P, Vollmer G, Binaglia M, Ramos B L, Riolo F, Roldan-Torres R, Grasl-Kraupp B. 2020. Risk assessment of glycoalkaloids in feed and food,in particular in potatoes and potato-derived products. European Food Safety Authority Journal, 18 (8):e6222.
[64]	Shoji T, Saito K. 2022. A jasmonate-responsive erf transcription factor regulates steroidal glycoalkaloid biosynthesis genes in eggplant. Plants, 11 (23):3336.
[65]	Silva T M S, Camara C A, Freire K R L, Silva T G D, Agra M D F, Bhattacharyya J. 2008. Steroidal glycoalkaloids and molluscicidal activity of Solanum asperum Rich. fruits. Journal of the Brazilian Chemical Society, 19 (5):1048-1052.
[66]	Sivasankara Pillai S, Dandurand L. 2021. Effect of steroidal glycoalkaloids on hatch and reproduction of the potato cyst nematodeglobodera pallida. Plant Disease, 105 (10):2975-2980. doi: 10.1094/PDIS-02-21-0247-RE pmid: 33754862
[67]	Sun F, Li S, He D, Cao G, Ni X, Tai G, Zhou Y, Wang D. 2010. Effects of glycoalkaloids from Solanum plants on cucumber root growth. Phytochemistry, 71 (13):1534-1538.
[68]	Sun Fang. 2007. The study of the structures and allelopathy of glycoalkalods from Solanum nigrum L.[Ph. D. Dissertation]. Changchun: Northeast Normal University. (in Chinese)
	孙芳. 2007. 龙葵中糖苷生物碱的结构及其化感作用研究[博士论文]. 长春: 东北师范大学.
[69]	Sun Jin, Han Lijun, Yu Qingwen. 2006. Effect of seaweed extract on drought resistance of tomato and its mechanism. Acta Agriculturae Boreali-occidentalis Sinica,(1):127-134. (in Chinese)
	孙锦, 韩丽君, 于庆文. 2006. 海藻提取物对番茄抗旱性的影响及机理研究. 西北农业学报,(1):127-134.
[70]	Sun Rui, Shang Kun, Wu Qiqi, Shang Yufei, Lü Yuhong, Yue Changwu. 2023. Advances on lycopene biosynthesis and antioxidant research. Food Science and Technology, 48 (6):246-252. (in Chinese)
	孙瑞, 尚坤, 武琪琪, 尚雨霏, 吕玉红, 岳昌武. 2023. 番茄红素生物合成及抗氧化研究进展. 食品科技, 48 (6):246-252.
[71]	Sun Xiao, Yin Haochan, Zhang Zhantian, Song Wanlin, Yang Jianchao, Jiang Xueling, Zhang Guanghe, Liu Zhengyi, Ding Diandong, Li Baoguang. 2020. Effects of seaweed extract on rice yield and nutrient utilization. Jiangsu Agricultural Sciences, 48 (16):100-103. (in Chinese)
	孙晓, 尹皓婵, 张占田, 宋宛霖, 杨剑超, 姜学玲, 张广和, 刘正一, 丁殿东, 李宝光. 2020. 海藻提取物对水稻产量及养分利用的影响. 江苏农业科学, 48 (16):100-103.
[72]	Sun Y, Zhao Y, Wang L, Lou H X, Cheng A X. 2012. Cloning and expression analysis of squalene synthase,a key enzyme involved in antifungal steroidal glycoalkaloids biosynthesis from Solanum nigrum. Drug Discoveries & Therapeutics, 6 (5):242-248.
[73]	Wang C C, Sulli M, Fu D Q. 2017. The role of phytochromes in regulating biosynthesis of sterol glycoalkaloid in eggplant leaves. PLoS ONE, 12 (12):e189481.
[74]	Wang Fei, Li Yinke, Ye Xuejian, Wang Zhengyin. 2015. Effects of different potassium levels on eggplant solanine content and distribution. China Vegetables,(10):47-52. (in Chinese)
	王菲, 李银科, 叶学见, 王正银. 2015. 不同钾水平对茄子茄碱含量和分配的影响. 中国蔬菜,(10):47-52.
[75]	Wang Qian, Liu Weidong, Zhu Shinong, Cui Qunxiang, Zhang Aihui, Wang Zhangyi. 2015. Grey correlation analysis between nutritional quality and main agronomic traits of eggplant. Jiangsu Agricultural Sciences, 43 (12):184-187. (in Chinese)
	王倩, 刘卫东, 朱士农, 崔群香, 张爱慧, 王长义. 2015. 茄子营养品质与主要农艺性状的灰色关联分析. 江苏农业科学, 43 (12):184-187.
[76]	Wang Yanzhang, Zhu Xuan, Bian Shengzhen. 2000. Changes of α-tomatine in tomato fruits and its fungistasis during ripening. Journal of Xinjiang Agricultural University,(2):35-37. (in Chinese)
	王彦章, 朱璇, 卞生珍. 2000. 番茄成熟过程中番茄碱含量的变化及其抑菌作用. 新疆农业大学学报,(2):35-37.
[77]	Wang Zhenyu, Zhang Yaoguang, Zhu Min, Jiang Li, Pan Hao, Ma Xiaojiang, Yu Qing. 2022. Laboratory analysis and diagnosis of an imported case of kala-czar caused by Leishmania infantum in Shanghai City. Journal of Pathogen Biology, 17 (3):283-287. (in Chinese)
	王真瑜, 张耀光, 朱民, 江莉, 潘浩, 马晓疆, 余晴. 2022. 上海市1例输入性婴儿利什曼原虫引起的黑热病实验室检测与溯源分析. 中国病原生物学杂志, 17 (3):283-287.
[78]	Wu Xueru, Zheng Shiqin, Yan Zhanpeng, Chen Shuang, Zhang Wen, Miao Lin, Zhang Xiuhua. 2019. Inductive effect of solamargine on the apoptosis of human esophageal cancer KYSE 150 cells and its action mechanism. Journal of Medical Postgraduates, 32 (8):803-808. (in Chinese)
	巫雪茹, 郑世勤, 严展鹏, 陈双, 张雯, 缪林, 张秀华. 2019. 澳洲茄边碱诱导食管癌细胞KYSE150凋亡及其机制研究. 医学研究生学报, 32 (8):803-808.
[79]	Yang Yalun, Guo Yanzhi, Sun Junmao. 2017. Present status and future prospect for potato industry in China. Journal of Agricultural Science and Technology, 19 (1):29-36. (in Chinese) doi: 10.13304/j.nykjdb.2016.202
	杨雅伦, 郭燕枝, 孙君茂. 2017. 我国马铃薯产业发展现状及未来展望. 中国农业科技导报, 19 (1):29-36. doi: 10.13304/j.nykjdb.2016.202
[80]	Yamashoji S, Matsuda T. 2013. Synergistic cytotoxicity induced by α-solanine and α-chaconine. Food Chemistry, 141 (2):669-674. doi: 10.1016/j.foodchem.2013.03.104 pmid: 23790833
[81]	Yu Chunxia, Li Bingshi, Li Feng, Liang Yi. 2007. The medical value of lycopene. Northern Horticulture,(12):63-65. (in Chinese)
	于春霞, 李炳诗, 李峰, 梁毅. 2007. 番茄红素的医学价值. 北方园艺,(12):63-65.
[82]	Zhang Ming, Li Dun, Chen Yiben, Fang Feng, Luo Xuetao. 2006. Research progress in acetylcholinesterase molecular biology. Agrochemicals,(1):8-11. (in Chinese)
	张明, 李盾, 陈仪本, 方峰, 罗雪桃. 2006. 乙酰胆碱酯酶分子生物学研究进展. 农药,(1):8-11.
[83]	Zhao D, Zhao Y, Chen S, Kennelly E J. 2021. Solanum steroidal glycoalkaloids:structural diversity,biological activities,and biosynthesis. Natural Product Reports, 38 (8):1423-1444.
[84]	Zhao Xuesong, Gao Ling, Wang Juan, Xu Wenjing, Zhou Yifa. 2009. Antifungal activity of five solanaceous glycoalkaloidsand their mixtures against phytopathogenic fungi Cercosporella brassicae and Alternariaporri. Natural Product Research and Development, 21 (1):36-43. (in Chinese)
	赵雪淞, 高聆, 王娟, 徐文静, 周义发. 2009. 五种茄科糖苷生物碱及其混合物的抗真菌活性研究. 天然产物研究与开发, 21 (1):36-43.
[85]	Zhong Y, Li S, Chen L, Liu Z, Luo X, Xu P, Chen L. 2018. In vivo toxicity of solasonine and its effects on CYP 450 family gene expression in the livers of male mice from four strains. Toxins, 10 (12):487.
[86]	Zhou Baoli, Li Zhiwen, Ding Yuwen, Liu Xiang. 2009. Allelopathic effect of glyalkaloids in eggplant roots on five kinds of vegetables and its correlation analysis. Ecology and Environmental Sciences, 18 (1):310-316. (in Chinese)
	周宝利, 李志文, 丁昱文, 刘翔. 2009. 茄子(Solanum melomgena L.)根系糖苷生物碱对5种蔬菜作物的化感效应及相关分析. 生态环境学报, 18 (1):310-316. doi: 10.16258/j.cnki.1674-5906(2009)01-0310-07
[87]	Zhou Qianyi, Li Yi, Han Rui, Tian Jie. 2022. Research progress of using plant growth promoting rhizobacteria to alleviate continuous cropping obstacles of horticultural crops. Chinese Journal of Ecology, 41 (9):1845-1852. (in Chinese) doi: 10.13292/j.1000-4890.202209.018
	周倩怡, 李屹, 韩睿, 田洁. 2022. 根际促生菌缓解园艺作物连作障碍的研究进展. 生态学杂志, 41 (9):1845-1852.
[88]	Zou Xuexiao, Ma Yanqing, Dai Xiongze, Li Xuefeng, Yang Sha. 2020. Spread and industry development of pepper in China. Acta Horticulturae Sinica, 47 (9):1715-1726. (in Chinese) doi: 10.16420/j.issn.0513-353x.2020-0103
	邹学校, 马艳青, 戴雄泽, 李雪峰, 杨莎. 2020. 辣椒在中国的传播与产业发展. 园艺学报, 47 (9):1715-1726.

Progress in the Study of Glycosidealkaloids and Their Biological Activities in Solanaceae Vegetable

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