Abstract: Using the model of the major gene plus polygene of quantitative traits，a joint analysis of six-generations was performed from cross between a sweet pepper N1345 with high resistance to phythophtora blight and a highly susceptible hot pepper N1308. F2 population was analysed with EST-SSR and SSR molecular markers. It was showed that the resistance to Phythophtora blight of N1345 was controlled by two major genes（B-1-1）with equal additive and dominant effects. And the major genes heritabilities of B1，B2，F2 were 63.43%，82.32% and 83.46%，respectively. Two EST-SSR markers including E73 and E318 had significant minus correlation with desease indexes of Phythophtora capsici，with correlation coefficients–0.6296，–0.5492 separately（P < 0.01）. It showed that the two markers were closely linked to genes of resistance to Phytophtora blight. Furthermore，the 2 EST-SSR markers had same speration in 22 pepper lines，and in 6 out 22 lines the resistance or susceptivity to Phythophtora wasn’t coincident with marker separation.

Key words: sweet pepper, resistance to Phythophtora blight, inheritance, EST-SSR