Abstract: RILs（F2S8）populations and six generations（P1，P2，F1，B1，B2，F2）derived from a cross of PI296341-FR（resistant） and 97103（susceptible）were used to investigate the inheritance of resistance to race 2 of Fusarium oxysporum f. sp. niveurm. Using the mixed model of major gene plus polygene，the resistance to race 2 of Fusarium oxysporum was showed to fit one pair of additive-major genes plus additive-dominant polygene model（D-2 model）. In B1，B2 and F2 populations，the heritability of major genes with recessive effect was estimated to be 31.8%，23.4% and 48.6% respectively，and the polygene heritability ranged from 16.5% to 43.9%. Meanwhile，three linkage major genes with equal additive effect（F-3）were found to govern the inheritance of resistance to race 2 in the RILs（F2S8） populations，and the inheritance of major genes was estimated to be 66.2%，additive effect was–0.51. The recombinant rate between three major genes was about 0.16. This result indicated that the resistance to race 2 of Fusarium oxysporum in PI296341-FR was controlled by both major and minor genes，and the cumulative value for additive and dominant effects of minor genes were respectively higher than that of major genes.

Key words: atermelon, Fusarium oxysporum, race 2, resistance, inheritance