Abstract: Phytoplasma can cause many plants witches’ broom，leaf shrinkage，purple tops，fruit and flower deformity. In recent years，potato phytoplasma disease has severely influenced potato quality and yield. The transmission characteristics and taxonomic studies of phytoplasma disease were described firstly. And the current status of phytoplasma genome and plasmid research，research progress of secretory proteins，host resistance genes，and pathogenesis mechanisms were summarized. Then several potato phytoplasma diseases were illustrated，the research difficulty and tendency of phytoplasma disease were also discussed. This review can provide reference to phytoplasma disease research，rapid detection in field and epidemic forecasting of phytoplasma disease，dig out phytoplasmas core function genes and potato disease resistance breeding.