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Acta Horticulturae Sinica ›› 2021, Vol. 48 ›› Issue (4): 719-732.doi: 10.16420/j.issn.0513-353x.2020-0540

• Reviews • Previous Articles     Next Articles

Review of Base Editing Technology and its Application in Crop Genetic Improvement

LI Guobin, AI Guo, WEI Jing, ZHANG Junhong()   

  1. Key Laboratory of Horticultural Plant Biology,Ministry of Education,Huazhong Agricultural University,College of Horticulture and Forestry Sciences,Wuhan 430070,China
  • Received:2020-12-23 Online:2021-04-25 Published:2021-04-29
  • Contact: ZHANG Junhong E-mail:zhangjunhng@mail.hzau.edu.cn

Abstract:

The base editing is a new technology developed on the basis of the CRISPR/Cas system that can precisely edit the genome. It includes cytosine base editor(CBE),adenine base editor(ABE)and the latest prime editing(PE). The cytosine base editor can convert C/G to T/A at the target site of the genome,the adenine base editor can convert the A/T to G/C,while the prime editing can realize all 12 types nucleotides replacing(C-T,G-A,A-G,T-C,C-A,C-G,G-C,G-T,A-C,A-T,T-A,T-G),and the bases insertion and deletion. This article makes a systematic introduction of the principles,development processes,respective advantages and disadvantages of the three base editors,and their applications and developments in crop genetic improvement. Meanwhile,It looks forward to the application prospects of base editing technology in crop breeding.

Key words: base editing, cytosine base editor(CBE), adenine base editor(ABE), prime editing(PE), crop development

CLC Number: